Breast-cancer-research - breast-cancer-research.com - Breast Cancer Research - Latest Articles
General Information:
Latest News:
Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT 27 Aug 2013 | 05:00 am
Epithelial-mesenchymal transition (EMT) programs require the expression of a variety of so-called master regulators of EMT, including members of the Snail, Zeb, and Twist transcription factor families...
Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis 23 Aug 2013 | 05:00 am
IntroductionDNA methylation-induced silencing of genes encoding tumor suppressors is common in many types of cancer, but little is known about how such epigenetic silencing can contribute to tumor met...
LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling 23 Aug 2013 | 05:00 am
IntroductionLysyl oxidase-like 2 (LOXL2) is a matrix remodeling enzyme that has been shown to play a key role in invasion and metastasis of breast carcinoma cells. However, very little is known about ...
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype 23 Aug 2013 | 05:00 am
IntroductionEstrogen receptor (ER) and progesterone receptor (PR) testing are performed in the evaluation of breast cancer. While the clinical utility of ER as a predictive biomarker to identify patie...
PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer 23 Aug 2013 | 05:00 am
IntroductionAlthough a substantial proportion of male breast cancers (MBCs) are hereditary, the molecular pathways that are activated are unknown. We therefore examined the frequency and clinicopathol...
MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer 23 Aug 2013 | 05:00 am
IntroductionMicroRNAs are small non-coding RNAs that are involved in the post-transcriptional negative regulation of mRNAs. MicroRNA 510 (miR-510) was initially shown to have a potential oncogenic rol...
Effect of continuous statistically standardized measures of estrogen and progesterone receptors on disease-free survival in NCIC CTG MA.12 trial and B... 23 Aug 2013 | 05:00 am
IntroductionWe hypothesized improved inter-laboratory comparability of estrogen receptor (ER) and progesterone receptor (PgR) across different assay methodologies with adjunctive statistical standardi...
HIF-1alpha/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs) 15 Aug 2013 | 05:00 am
IntroductionCarcinoma-associated fibroblasts (CAFs) play a pivotal role in cancer progression by contributing to invasion, metastasis and angiogenesis. Solid tumors possess a unique microenvironment c...
Evidence for a multipotent mammary progenitor with pregnancy-specific activity 15 Aug 2013 | 05:00 am
IntroductionThe mouse mammary gland provides a powerful model system for studying processes involved in epithelial tissue development. Although markers that enrich for mammary stem cells and progenito...
Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells 12 Aug 2013 | 05:00 am
IntroductionSignal transducers and activators of transcription 3 (STAT3) signaling is constitutively activated in various cancers including breast cancer, and has emerged as a novel potential anti-can...
