Fasebj - fasebj.org - The FASEB Journal current issue
General Information:
Latest News:
CrbpI regulates mammary retinoic acid homeostasis and the mammary microenvironment [Research Communications] 30 Apr 2013 | 08:01 am
Cellular retinol-binding protein, type I (CrbpI), encoded by retinol-binding protein, type 1 ( Rbp1 ), is a chaperone of vitamin A (retinol) that is epigenetically silenced in ~25% of human breast can...
Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y6 activation of the phospholipase C/inositol trisphosphate pathway ... 30 Apr 2013 | 08:01 am
Bladder dysfunction characterized by abnormal bladder smooth muscle (BSM) contractions is pivotal to the disease process in overactive bladder, urge incontinence, and spinal cord injury. Purinergic si...
The mechanical consequences of load bearing in the equine third metacarpal across speed and gait: the nonuniform distributions of normal strain, shear... 30 Apr 2013 | 08:01 am
Distributions of normal strain, shear strain, and strain energy density (SED) were determined across the midshaft of the third metacarpal (MCIII, or cannon bone) of 3 adult thoroughbred horses as a fu...
Genetic control of estrogen-regulated transcriptional and cellular responses in mouse uterus [Research Communications] 30 Apr 2013 | 08:01 am
The uterotropic response of the uterus to 17β-estradiol (E 2 ) is genetically controlled, with marked variation observed depending on the mouse strain studied. Previous genetic studies from our labora...
Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression [Research Communications] 30 Apr 2013 | 08:01 am
β-Site amyloid precursor protein convertase enzyme 1 (BACE1), a type I transmembrane aspartyl protease required to cleave amyloid precursor protein for releasing a toxic amyloid peptide, also cleaves ...
Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice [Research Communications] 30 Apr 2013 | 08:01 am
Excessively increased peripheral vasoconstriction is a hallmark of heart failure (HF). Here, we show that in mice with systolic HF post–myocardial infarction, the myogenic tone of third-order mesenter...
The cellular prion protein traps Alzheimer's A{beta} in an oligomeric form and disassembles amyloid fibers [Research Communications] 30 Apr 2013 | 08:01 am
There is now strong evidence to show that the presence of the cellular prion protein (PrP C ) mediates amyloid-β (Aβ) neurotoxicity in Alzheimer's disease (AD). Here, we probe the molecular details of...
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation [Research Communications] 30 Apr 2013 | 08:01 am
There has been much recent interest in lysophosphatidic acid (LPA) signaling through one of its receptors, LPA 1 , in fibrotic diseases, but the mechanisms by which LPA-LPA 1 signaling promotes pathol...
A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent ... 30 Apr 2013 | 08:01 am
Most neurodegenerative diseases are linked to aberrant accumulation of aggregation-prone proteins. Among them, Huntington's disease (HD) is caused by an expanded polyglutamine repeat stretch in the N ...
Novel role of sorting nexin 5 in renal D1 dopamine receptor trafficking and function: implications for hypertension [Research Communications] 30 Apr 2013 | 08:01 am
The D 1 dopamine receptor (D 1 R) is widely expressed in the kidney and plays a crucial role in blood pressure regulation. Although much is known about D 1 R desensitization, especially through G-prot...
