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Photo-controllable aptamer 12 Sep 2009 | 08:00 am
We have successfully developed a new method for photoregulation of G-quadruplex formation using cis-trans photoisomerization of the photochromic nucleobase 8FVG. Our photo-controllable quadruplexes ca...
Photo-switching of vinylpyrene-substituted 2'-deoxyguanosine and its application 12 Sep 2009 | 08:00 am
We synthesized C8-vinylpyrene-substituted 2'-deoxyguanosine VPyG and studied the photoinduced reversible E–Z isomerization. When E-isomer was irradiated with visible light (>420 nm), E- to Z-isomeriza...
Regulation of duplex DNA strand displacement by visible light sensitive bis-peptide nucleic acid 12 Sep 2009 | 08:00 am
A novel visible light sensitive azobenzene (AZO) was synthesized and introduced into bis-peptide nucleic acid (bis-PNA), which consists of two homopyrimidine PNA strands, as a linker. Visible light ir...
Line up base pairs and intercalators one by one in a stable duplex 12 Sep 2009 | 08:00 am
A stable double helix involving alternating base pairs and azobenzene moieties was constructed. In this supramolecule, base pairs and azobenzenes are lined up one by one to form an interstrand-wedged ...
Development of light-responsive BNA toward the spatiotemporal control of gene expression 12 Sep 2009 | 08:00 am
We designed and synthesized light-responsive BNA (bridged nucleic acid), which has a photolabile group at the bridged structure. Light-Responsive BNA can change its structure by a two stages process: ...
Photochemical generation and reaction of 2'-substituted analogues of C4'-oxidized abasic lesion 12 Sep 2009 | 08:00 am
The C4'-oxidized abasic site (1) is one of the oxidatively damaged DNA lesions induced by antitumor bleomycins. The reactivity of 1 with amine under neutral conditions giving lactam 2 and its structur...
Acceleration of guanine oxidation under visible light irradiation by photon upconversion based on triplet-triplet annihilation 12 Sep 2009 | 08:00 am
We report the fluorescent polymer complex which can show fluorescence emission at 380 nm with the excitation of 520 nm in aqueous media. This photon upconversion based on triplet–triplet annihilation ...
Electronic structure and UV absorption spectra of metal-mediate DNA: an approach from theoretical chemistry 12 Sep 2009 | 08:00 am
We theoretically evaluated the stability, UV-Vis spectra and possibility of stacking of [S-M(II)-S] (M=Ni, Pd, Pt, S: hydroxypyridonethione) by means of the density functional theory (DFT). From the v...
Radiolytic one-electron reductive cyclization of oligodeoxynucleotides possessing a disulfide bond 12 Sep 2009 | 08:00 am
Radiolytic one-electron reduction of oligodeoxynucleotides (ODNs) possessing a disulfide bond induced strand exchange reaction in a hypoxia selective manner. In this study, we attempted to apply this ...
Handy and prompt DNA separation using PNA with internal disulfide bond 12 Sep 2009 | 08:00 am
PNA (peptide nucleic acid) is a DNA analogue which has a peptide backbone. PNA is very useful as a recognition probe because of its immensely high affinity to DNA. In this study, we used PNA as a DNA ...
