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Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila 13 May 2013 | 04:44 pm
During autophagy, phagophores capture portions of cytoplasm and form double-membrane autophagosomes to deliver cargo for lysosomal degradation. How autophagosomes gain competence to fuse with late end...
The asymmetric segregation of damaged proteins is stem cell-type dependent 13 May 2013 | 04:44 pm
Asymmetric segregation of damaged proteins (DPs) during mitosis has been linked in yeast and bacteria to the protection of one cell from aging. Recent evidence suggests that stem cells may use a simil...
Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint 13 May 2013 | 04:44 pm
The DNA damage response (DDR) pathway and its core component tumor suppressor p53 block cell cycle progression after genotoxic stress and represent an intrinsic barrier preventing cancer development. ...
The cell biology of disease: Cellular and molecular mechanisms underlying muscular dystrophy 13 May 2013 | 04:44 pm
The muscular dystrophies are a group of heterogeneous genetic diseases characterized by progressive degeneration and weakness of skeletal muscle. Since the discovery of the first muscular dystrophy ge...
Route to destruction: Autophagosomes SNARE lysosomes 13 May 2013 | 04:44 pm
Autophagy allows cells to encapsulate parts of their cytosol into unique double-membrane structures. These autophagosomes mature to fuse with lysosomes and deliver the enclosed contents for degradatio...
Victor Ambros: The broad scope of microRNAs 13 May 2013 | 04:44 pm
Once, we thought we understood all there was to know about how gene expression is regulated: A cell can tinker with the expression level of a given protein’s messenger RNA by modifying the activity, a...
Making short work of p53 13 May 2013 | 04:44 pm
Kleiblova et al. have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53 ( 1 ). FOCAL POINT (Left to right) Libor Macurek, Zdenek Kleibl, Petra Klei...
Three's not a crowd for actin nucleators 13 May 2013 | 04:44 pm
Bil1 (green) and Bud6 (red) colocalize at the bud necks (arrowheads) of yeast cells. Graziano et al. reveal a new mechanism for controlling actin nucleation. Proteins that spur actin assembly often wo...
Why metaphase chromosomes wander 13 May 2013 | 04:44 pm
Sister kinetochores (green dots) at the edge of a PtK1 cell (left) move little, whereas kinetochores near the middle of the cell (right) oscillate. Civelekoglu-Scholey et al. explain why some metaphas...
Progerin guilty of size discrimination 13 May 2013 | 04:44 pm
Tpr (red) accumulates in the nuclei of cells from a healthy person (left), but it remains in the cytoplasm of cells from an HGPS patient (right). A mutant protein responsible for Hutchinson-Gilford...
