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Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood 26 Aug 2013 | 07:59 pm
Kaposi sarcoma (KS), a human herpes virus 8 (HHV-8; also called KSHV)–induced endothelial tumor, develops only in a small fraction of individuals infected with HHV-8. We hypothesized that inborn error...
DNA repair genes are selectively mutated in diffuse large B cell lymphomas 26 Aug 2013 | 07:59 pm
DNA repair mechanisms are fundamental for B cell development, which relies on the somatic diversification of the immunoglobulin genes by V(D)J recombination, somatic hypermutation, and class switch re...
The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils 26 Aug 2013 | 07:59 pm
Tumor-infiltrating immune cells can be conditioned by molecules released within the microenvironment to thwart antitumor immune responses, thereby facilitating tumor growth. Among immune cells, neutro...
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma 26 Aug 2013 | 07:59 pm
Treatment with monoclonal antibody specific for cytotoxic T lymphocyte–associated antigen 4 (CTLA-4), an inhibitory receptor expressed by T lymphocytes, has emerged as an effective therapy for the tre...
Activating Fc {gamma} receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies 26 Aug 2013 | 07:59 pm
Fc receptor (FcR) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that target tumor necrosis factor receptor (TNFR) family member...
Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease 26 Aug 2013 | 07:59 pm
Interleukin (IL) 12 and IL23 are two related heterodimeric cytokines produced by antigen-presenting cells. The balance between these two cytokines plays a crucial role in the control of Th1/Th17 respo...
A role for gut-associated lymphoid tissue in shaping the human B cell repertoire 26 Aug 2013 | 07:59 pm
We have tracked the fate of immature human B cells at a critical stage in their development when the mature B cell repertoire is shaped. We show that a major subset of bone marrow emigrant immature hu...
Multicolor fate mapping of Langerhans cell homeostasis 26 Aug 2013 | 07:59 pm
Langerhans cells (LCs) constitute a network of immune sentinels in the skin epidermis that is seeded during embryogenesis. Whereas the development of LCs has been extensively studied, much less is kno...
Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth 26 Aug 2013 | 07:59 pm
Oxysterols are oxidized derivatives of cholesterol that are generated enzymatically or through autoxidation. Initially identified as important lipid signaling molecules in the context of atheroscleros...
Fc{gamma} receptors enable anticancer action of proapoptotic and immune-modulatory antibodies 26 Aug 2013 | 07:59 pm
Antibodies have important roles in controlling cellular immunity through interaction with activating or inhibitory Fc receptors (FcRs). FcR engagement can facilitate receptor cross-linking on target c...
