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[Biochemistry] Caspase Substrates and Inhibitors 1 Aug 2013 | 06:00 pm
Caspases are proteases at the heart of networks that govern apoptosis and inflammation. The past decade has seen huge leaps in understanding the biology and chemistry of the caspases, largely through ...
[Cell Signaling] Complexity of Receptor Tyrosine Kinase Signal Processing 1 Aug 2013 | 06:00 pm
Our knowledge of molecular mechanisms of receptor tyrosine kinase (RTK) signaling advances with ever-increasing pace. Yet our understanding of how the spatiotemporal dynamics of RTK signaling control ...
[Biochemistry] Structural and Functional Properties of Platelet-Derived Growth Factor and Stem Cell Factor Receptors 1 Aug 2013 | 06:00 pm
The receptors for platelet-derived growth factor (PDGF) and stem cell factor (SCF) are members of the type III class of PTK receptors, which are characterized by five Ig-like domains extracellularly a...
[Molecular Biology] DNA Replication Timing 1 Aug 2013 | 06:00 pm
Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin structure, and genome evolution. Recent advances in genome-scale mapping of replication kinetics have allowe...
[Molecular Biology] Chromatin and DNA Replication 1 Aug 2013 | 06:00 pm
The size of a eukaryotic genome presents a unique challenge to the cell: package and organize the DNA to fit within the confines of the nucleus while at the same time ensuring sufficient dynamics to a...
[Molecular Pathology] The Role of Mitochondria in Cellular Iron-Sulfur Protein Biogenesis: Mechanisms, Connected Processes, and Diseases 1 Aug 2013 | 06:00 pm
Iron–sulfur (Fe/S) clusters belong to the most ancient protein cofactors in life, and fulfill functions in electron transport, enzyme catalysis, homeostatic regulation, and sulfur activation. The synt...
[Molecular Biology] Mammalian Transcription-Coupled Excision Repair 1 Aug 2013 | 06:00 pm
Transcriptional arrest caused by DNA damage is detrimental for cells and organisms as it impinges on gene expression and thereby on cell growth and survival. To alleviate transcriptional arrest, cells...
[Cell Signaling] DNA Damage Response: Three Levels of DNA Repair Regulation 1 Aug 2013 | 06:00 pm
Genome integrity is challenged by DNA damage from both endogenous and environmental sources. This damage must be repaired to allow both RNA and DNA polymerases to accurately read and duplicate the inf...
[Cell Signaling] Endoplasmic Reticulum Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathway 1 Aug 2013 | 06:00 pm
Hundreds of eukaryotic membrane proteins are anchored to membranes by a single transmembrane domain at their carboxyl terminus. Many of these tail-anchored (TA) proteins are posttranslationally target...
[Biochemistry] N-Linked Protein Glycosylation in the Endoplasmic Reticulum 1 Aug 2013 | 06:00 pm
The attachment of glycans to asparagine residues of proteins is an abundant and highly conserved essential modification in eukaryotes. The N-glycosylation process includes two principal phases: the as...
