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Computational detection of abundant long-range nucleotide covariation in Drosophila genomes [BIOINFORMATICS] 16 Aug 2013 | 07:00 pm
Functionally important nucleotide base-pairing often manifests itself in sequence alignments in the form of compensatory base changes (covariation). We developed a novel index-based computational meth...
RNA structural motif recognition based on least-squares distance [BIOINFORMATICS] 16 Aug 2013 | 07:00 pm
RNA structural motifs are recurrent structural elements occurring in RNA molecules. RNA structural motif recognition aims to find RNA substructures that are similar to a query motif, and it is importa...
Conservation of structure and mechanism by Trm5 enzymes [REPORT] 16 Aug 2013 | 07:00 pm
Enzymes of the Trm5 family catalyze methyl transfer from S-adenosyl methionine (AdoMet) to the N1 of G37 to synthesize m1G37-tRNA as a critical determinant to prevent ribosome frameshift errors. Trm5 ...
RNase III is required for localization to the nucleoid of the 5' pre-rRNA leader and for optimal induction of rRNA synthesis in E. coli [REPORT] 16 Aug 2013 | 07:00 pm
It has recently been demonstrated that ribosomes are preferentially localized outside the nucleoid in Escherichia coli, but little is known about the spatial regulation of pre-rRNA processing. In this...
Translation of CGA codon repeats in yeast involves quality control components and ribosomal protein L1 [ARTICLES] 16 Aug 2013 | 07:00 pm
Translation of CGA codon repeats in the yeast Saccharomyces cerevisiae is inefficient, resulting in dose-dependent reduction in expression and in production of an mRNA cleavage product, indicative of ...
Mechanism of activation of elongation factor Tu by ribosome: Catalytic histidine activates GTP by protonation [ARTICLES] 16 Aug 2013 | 07:00 pm
Elongation factor Tu (EF-Tu) is central to prokaryotic protein synthesis as it has the role of delivering amino-acylated tRNAs to the ribosome. Release of EF-Tu, after correct binding of the EF-Tu:aa-...
Crystal structure of 3WJ core revealing divalent ion-promoted thermostability and assembly of the Phi29 hexameric motor pRNA [ARTICLES] 16 Aug 2013 | 07:00 pm
The bacteriophage phi29 DNA packaging motor, one of the strongest biological motors characterized to date, is geared by a packaging RNA (pRNA) ring. When assembled from three RNA fragments, its three-...
The double-stranded RNA binding domain of human Dicer functions as a nuclear localization signal [ARTICLES] 16 Aug 2013 | 07:00 pm
Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA precursors and double-stranded RNA into ~21-nt-long products ultimately triggering sequence-dependent g...
An RpoS-dependent sRNA regulates the expression of a chaperone involved in protein folding [ARTICLES] 16 Aug 2013 | 07:00 pm
Small noncoding RNAs (sRNAs) are usually expressed in the cell to face a variety of stresses. In this report we disclose the first target for SraL (also known as RyjA), a sRNA present in many bacteria...
Predicted group II intron lineages E and F comprise catalytically active ribozymes [ARTICLES] 16 Aug 2013 | 07:00 pm
Group II introns are self-splicing, retrotransposable ribozymes that contribute to gene expression and evolution in most organisms. The ongoing identification of new group II introns and recent bioinf...
