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Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice [Research Articles] 7 May 2013 | 02:54 pm
Exposure to ambient particulate matter (PM) is a risk factor for cardiovascular diseases. The redox-active ultrafine particles (UFPs) promote vascular oxidative stress and inflammatory responses. We h...
Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglet... 7 May 2013 | 02:54 pm
The dose-responsiveness of plasma oxylipins to incremental dietary intake of arachidonic acid (20:4n-6; ARA) and docosahexaenoic acid (22:6n-3; DHA) was determined in piglets. Piglets randomly receive...
Comparison of apoA-I helical structure and stability in discoidal and spherical HDL particles by HX and mass spectrometry [Research Articles] 7 May 2013 | 02:54 pm
Elucidation of apoA-I secondary structure in spherical plasma HDL particles is essential for understanding HDL structure and function at the molecular level. To provide this information, we have appli...
Surface pressure-dependent conformation change of apolipoprotein-derived amphipathic {alpha}-helices [Research Articles] 7 May 2013 | 02:54 pm
Amphipathic α-helices (AαH) are the primary structural motif of exchangeable apolipoproteins. AαHs in exchangeable apolipoproteins adsorb, remodel, and desorb at the surface of plasma lipoproteins in ...
Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice [Research Articles] 7 May 2013 | 02:54 pm
Reverse cholesterol transport (RCT) can proceed through the classic hepatobiliary route or through the nonbiliary transintestinal cholesterol efflux (TICE) pathway. Scavenger receptor class B type I (...
PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment [Research Articles] 7 May 2013 | 02:54 pm
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the LDL receptor (LDLR) at the cell surface and reroutes the internalized LDLR to intracellular degradation. In this study, we have shown...
S-nitrosylation of ARH is required for LDL uptake by the LDL receptor [Research Articles] 7 May 2013 | 02:54 pm
The LDL receptor (LDLR) relies upon endocytic adaptor proteins for internalization of lipoproteins. The results of this study show that the LDLR adaptor autosomal recessive hypercholesterolemia protei...
Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia [Research Articles] 7 May 2013 | 02:54 pm
Mutations in microsomal triglyceride transfer protein (MTP) cause abetalipoproteinemia (ABL), characterized by the absence of plasma apoB-containing lipoproteins. In this study, we characterized the e...
A novel JNK2/SREBP-1c pathway involved in insulin-induced fatty acid synthesis in human adipocytes [Research Articles] 7 May 2013 | 02:54 pm
Insulin plays important roles in apoptosis and lipid droplet (LD) formation, and it is one of the determinants involved in increasing fat mass. However, the mechanisms underlying insulin-induced enlar...
Shorthand notation for lipid structures derived from mass spectrometry [Special Reports] 7 May 2013 | 02:54 pm
There is a need for a standardized, practical annotation for structures of lipid species derived from mass spectrometric approaches; i.e., for high-throughput data obtained from instruments operating ...
