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GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1{alpha} destabilization 2 Aug 2013 | 02:28 pm
The metabolism that sustains cancer cells is adapted preferentially to glycolysis, even under aerobic conditions (Warburg effect). This effect was one of the first alterations in cancer cells recogniz...
Androgen-responsive Serum Response Factor target genes regulate prostate cancer cell migration 2 Aug 2013 | 02:28 pm
Progression of prostate cancer (CaP) relies on androgen receptor (AR) signaling, but AR-dependent events that underlie the lethal phenotype remain unknown. Recently, an indirect mechanism of androgen ...
Regulator of G protein signaling 6 is a novel suppressor of breast tumor initiation and progression 2 Aug 2013 | 02:28 pm
Breast cancer is a large global health burden and the most frequently diagnosed malignancy in women worldwide. Here, we utilize RGS6–/– mice to interrogate the role of regulator of G protein signaling...
DNA methylation and histone modifications of Wnt genes by genistein during colon cancer development 2 Aug 2013 | 02:28 pm
This study aims to elucidate the epigenetic mechanisms by which genistein (GEN) maintains a normal level of WNT genes during colon cancer development. We have reported that soy protein isolate (SPI) a...
TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways 2 Aug 2013 | 02:28 pm
The epithelial–mesenchymal transition (EMT) has been implicated in various pathophysiological processes, including cancer cell migration and distal metastasis. Reactive oxygen species (ROS) and insuli...
Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma 2 Aug 2013 | 02:28 pm
The POU transcription factor OCT4 is a pleiotropic regulator of gene expression in embryonic stem cells. Recent studies demonstrated that OCT4 is aberrantly expressed in multiple types of human cancer...
Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population 2 Aug 2013 | 02:28 pm
Genome-wide association studies have identified multiple genetic variants associated with risk of esophageal squamous-cell carcinoma (ESCC) in Chinese populations. We examined whether these genetic fa...
Genetic ancestry modifies the association between genetic risk variants and breast cancer risk among Hispanic and non-Hispanic white women 2 Aug 2013 | 02:28 pm
Hispanic women in the USA have lower breast cancer incidence than non-Hispanic white (NHW) women. Genetic factors may contribute to this difference. Breast cancer genome-wide association studies (GWAS...
Fried meat intake is a risk factor for lung adenocarcinoma in a prospective cohort of Chinese men and women in Singapore 2 Aug 2013 | 02:28 pm
Probable human carcinogens are generated during Chinese-style high-temperature cooking of meat and have been detected in the ambient air and on the meat surface. Although the inhalation of these compo...
Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China 2 Aug 2013 | 02:28 pm
Qidong City, China, has had high liver cancer incidence from endemic hepatitis B virus (HBV) infection and dietary exposure to aflatoxin. Based on etiologic studies, we began interventions in 1980 to ...
