Physiology - ajpendo.physiology.org - AJP: Endocrinology and Metabolism current issue
General Information:
Latest News:
The role of CaMKII in regulating GLUT4 expression in skeletal muscle 1 Aug 2012 | 05:30 pm
Contractile activity during physical exercise induces an increase in GLUT4 expression in skeletal muscle, helping to improve glucose transport capacity and insulin sensitivity. An important mechanism ...
RIFL aims to be a new player in lipid metabolism 1 Aug 2012 | 05:30 pm
RIFL (refeeding induced in fat and liver) is highly expressed in brown and white fat as well as in liver. In white adipose tissue and liver, RIFL expression is induced by refeeding and is also elevate...
Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism 1 Aug 2012 | 05:30 pm
To identify new genes that are important in fat metabolism, we utilized the Lexicon-Genentech knockout database of genes encoding transmembrane and secreted factors and whole murine genome transcripti...
Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep 1 Aug 2012 | 05:30 pm
Placental insufficiency decreases fetal amino acid uptake from the placenta, plasma insulin concentrations, and protein accretion, thus compromising normal fetal growth trajectory. We tested whether a...
Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans 1 Aug 2012 | 05:30 pm
Lactose synthesis is believed to be rate limiting for milk production. However, understanding the molecular events controlling lactose synthesis in humans is still rudimentary. We have utilized our es...
Acute hypoxia induces hypertriglyceridemia by decreasing plasma triglyceride clearance in mice 1 Aug 2012 | 05:30 pm
Obstructive sleep apnea (OSA) induces intermittent hypoxia (IH) during sleep and is associated with elevated triglycerides (TG). We previously demonstrated that mice exposed to chronic IH develop elev...
Logistic model of glucose-regulated C-peptide secretion: hysteresis pathway disruption in impaired fasting glycemia 1 Aug 2012 | 05:30 pm
The present analysis tests the hypothesis that quantifiable disruption of the glucose-stimulated insulin-secretion dose-response pathway mediates impaired fasting glycemia (IFG) and type 2 diabetes me...
JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia 1 Aug 2012 | 05:30 pm
Cachexia, the metabolic dysregulation leading to sustained loss of muscle and adipose tissue, is a devastating complication of cancer and other chronic diseases. Interleukin-6 and related cytokines ar...
Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in o... 1 Aug 2012 | 05:30 pm
The orexigenic hormone ghrelin is important in diabetes because it has an inhibitory effect on insulin secretion. Ghrelin ablation in leptin-deficient ob/ob ( Ghrelin –/– : ob / ob ) mice increases in...
Developmental changes in embryonic hypothalamic neurons during prenatal fat exposure 1 Aug 2012 | 05:30 pm
Maternal consumption of a fat-rich diet during pregnancy, which causes later overeating and weight gain in offspring, has been shown to stimulate neurogenesis and increase hypothalamic expression of o...
