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Exercise, GLUT4, and Skeletal Muscle Glucose Uptake 30 Jul 2013 | 05:56 pm
Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose transporter w...
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation 30 Jul 2013 | 05:56 pm
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they control almost all aspects of a cell's life and death. These lipids gained tremendous research interest as pla...
11{beta}-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action 30 Jul 2013 | 05:56 pm
Glucocorticoid action on target tissues is determined by the density of "nuclear" receptors and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD) which catalyz...
Placebo and the New Physiology of the Doctor-Patient Relationship 30 Jul 2013 | 05:56 pm
Modern medicine has progressed in parallel with the advancement of biochemistry, anatomy, and physiology. By using the tools of modern medicine, the physician today can treat and prevent a number of d...
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding 30 Jul 2013 | 05:56 pm
Sepsis represents the host's systemic inflammatory response to a severe infection. It causes substantial human morbidity resulting in hundreds of thousands of deaths each year. Despite decades of inte...
Deubiquitylases From Genes to Organism 30 Jul 2013 | 05:56 pm
Ubiquitylation is a major posttranslational modification that controls most complex aspects of cell physiology. It is reversed through the action of a large family of deubiquitylating enzymes (DUBs) t...
Molecular Biology of Atherosclerosis 30 Jul 2013 | 05:56 pm
At least 468 individual genes have been manipulated by molecular methods to study their effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and many investigators...
T-Type Ca2+ Channels in Normal and Abnormal Brain Functions 30 Jul 2013 | 05:56 pm
Low-voltage-activated T-type Ca2+ channels are widely expressed in various types of neurons. Once deinactivated by hyperpolarization, T-type channels are ready to be activated by a small depolarizatio...
Nuclear Receptors in Bone Physiology and Diseases 15 Apr 2013 | 09:00 pm
During the last decade, our view on the skeleton as a mere solid physical support structure has been transformed, as bone emerged as a dynamic, constantly remodeling tissue with systemic regulatory fu...
Claudins and the Modulation of Tight Junction Permeability 15 Apr 2013 | 09:00 pm
Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes...
