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Antibody-guided photoablation of voltage-gated potassium currents 26 Aug 2013 | 07:59 pm
A family of 40 mammalian voltage-gated potassium (Kv) channels control membrane excitability in electrically excitable cells. The contribution of individual Kv channel types to electrophysiological si...
Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa 26 Aug 2013 | 07:59 pm
During passage through the female reproductive tract, mammalian sperm undergo a maturation process termed capacitation that renders sperm competent to produce fertilization. Capacitation involves a se...
Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels 26 Aug 2013 | 07:59 pm
Human ether-à-go-go–related gene (hERG, Kv11.1) potassium channels have unusually slow activation and deactivation kinetics. It has been suggested that, in fast-activating Shaker channels, a highly co...
Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels 26 Aug 2013 | 07:59 pm
Kv11.1 channels are critical for the maintenance of a normal heart rhythm. The flow of potassium ions through these channels is controlled by two voltage-regulated gates, termed "activation" and "inac...
Life and death of a cardiac calcium spark 26 Aug 2013 | 07:59 pm
Calcium sparks in cardiac myocytes are brief, localized calcium releases from the sarcoplasmic reticulum (SR) believed to be caused by locally regenerative calcium-induced calcium release (CICR) via c...
E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interac... 26 Aug 2013 | 07:59 pm
Mutations in cardiac myosin binding protein C (cMyBP-C) are prevalent causes of hypertrophic cardiomyopathy (HCM). Although HCM-causing truncation mutations in cMyBP-C are well studied, the growing nu...
Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles 26 Aug 2013 | 07:59 pm
RNA editing at the Q/R site near the apex of the pore loop of AMPA and kainate receptors controls a diverse array of channel properties, including ion selectivity and unitary conductance and susceptib...
Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear 26 Aug 2013 | 07:59 pm
The hyperpolarization-activated current, Ih, is carried by members of the Hcn channel family and contributes to resting potential and firing properties in excitable cells of various systems, including...
Interactions among DIV voltage-sensor movement, fast inactivation, and resurgent Na current induced by the NaV{beta}4 open-channel blocking peptide 26 Aug 2013 | 07:59 pm
Resurgent Na current flows as voltage-gated Na channels recover through open states from block by an endogenous open-channel blocking protein, such as the NaVβ4 subunit. The open-channel blocker and f...
Embracing the principles of the San Francisco Declaration of Research Assessment: Robert Balaban's Editorial 26 Aug 2013 | 07:59 pm
Early career scientists today face many obstacles in their effort to achieve an independent career, including stiff competition for grant funding and jobs. Many of these hurdles reappear throughout on...
