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Impaired sexual function in women with systemic lupus erythematosus: a cross-sectional study 20 Aug 2013 | 11:16 pm

Objective The objectives of this paper are to compare sexual function and distress in women with systemic lupus erythematosus (SLE) and in healthy controls; to determine the association between disea...

Targeted therapies in systemic lupus erythematosus 20 Aug 2013 | 11:16 pm

Systemic lupus erythematosus (SLE) is a chronic, multisystem disorder characterised by loss of tolerance to endogenous nuclear antigens and autoantibody formation. Recent insight into the immunopathog...

Q222R polymorphism in DNAse I gene is a risk factor for nephritis in South Indian SLE patients 20 Aug 2013 | 11:16 pm

Objective Systemic lupus erythematosus (SLE) is a multisystem disorder in which defective apoptotic clearance is considered to be an important factor in pathogenesis. DNAse I is associated with dispo...

Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region 20 Aug 2013 | 11:16 pm

A higher prevalence of depression in systemic lupus erythematosus (SLE) patients has been reported, though the mechanism underlying this phenomenon remains unclear. The present study was conducted to ...

Glucocorticoid downregulates expression of IL-12 family cytokines in systemic lupus erythematosus patients 20 Aug 2013 | 11:16 pm

Objective This study aims to investigate expression of interleukin 12 (IL-12) family cytokines IL-12, IL-23, IL-27 and IL-35 in systemic lupus erythematosus (SLE) patients and the effect of glucocort...

Physicochemical and immunological studies on mitochondrial DNA modified by peroxynitrite: implications of neo-epitopes of mitochondrial DNA in the eti... 20 Aug 2013 | 11:16 pm

Background and objective Recent evidence has demonstrated that mitochondria possess their own nitric oxide synthase (mtNOS) and can produce endogenous reactive-nitrogen-species (RNS) including peroxy...

'Focus on feet' - the effects of systemic lupus erythematosus: a narrative review of the literature 20 Aug 2013 | 11:16 pm

Background The manifestations of systemic lupus erythematosus (SLE) vary between individuals, from the severe and life-threatening renal and central nervous system involvement, to the involvement of ...

Physician-patient interactions and outcomes in systemic lupus erythematosus (SLE): a conceptual model 20 Aug 2013 | 11:16 pm

Objective The objective was to develop a conceptual model illustrating the relationships between the physician-patient relationship and patient outcomes, including health status and regimen satisfact...

Transcatheter aortic valve replacement for advanced valvular disease in active SLE and APS 20 Aug 2013 | 11:16 pm

Valvular heart disease is a relatively common finding in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS), sometimes necessitating valve surgery. Valve replacement may result in ...

Validation and evaluation of the German Brief Index of Lupus Damage (BILD) - a self-reported instrument to record damage in systemic lupus erythematos... 20 Aug 2013 | 11:16 pm

Introduction Damage is a very important predictor for outcome in systemic lupus erythematosus (SLE) and should be routinely documented. Patient-reported assessments for damage are rare and neither th...

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